ABSTRACT
Analysis of congenital syphilis in 455 infants and neonates between 1977-1991 in Children's Hospital, Bangkok, Thailand revealed 11 cases (2.4%) with evidence of congenital syphilitic nephrotic syndrome which were confirmed by clinical, serologic and laboratory findings, long bone x-rays and renal biopsy. Ages of all 11 cases were between 1 day to 2 months (mean 24 days); 6 were boys and 5 girls. Two of them died because of necrotizing enterocolitis and sepsis respectively; the mortality rate was 18%. The other nine had complete recovery following penicillin therapy.
Subject(s)
Bacteremia/etiology , Cause of Death , Diagnosis, Differential , Enterocolitis, Pseudomembranous/etiology , Female , Humans , Infant , Infant, Newborn , Male , Nephrosis/complications , Penicillins/therapeutic use , Population Surveillance , Syphilis, Congenital/complications , Thailand/epidemiology , Treatment Outcome , Treponema pallidumABSTRACT
A bacteriological study of children with respiratory infections in Bangkok during January to November 1976 revealed that 37% of the patients had symptoms and sign of bacterial pharyngotonsillitis. Twenty-six per cent of these children harboured Streptococcus pyogenes in their throats. The numbers of streptococci other than group A and Staphylococcus aureus were increased in the children with respiratory infections. However, Staph. aureus was found as the sole organism in children with exudate more often than in the children with only URI. The possible role of Staph. aureus in bacterial pharyngitis should not be ignored. Penicillin remains a drug of choice for the treatment of streptococcal pharyngitis. If penicillin is contraindicated, erythromycin should be preferred over lincomycin as a second choice of drug in order to avoid treatment failure if lincomycin resistant streptococci are present.